The bioinorganic chemistry and associated immunology of chronic beryllium disease

Brian L. Scott; T. Mark McCleskey; Anu Chaudhary; Elizabeth Hong-Geller; S. Gnanakaran

doi:10.1039/B718746G

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Chemical Communications

Issue 25, 2008

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The bioinorganic chemistry and associated immunology of chronic beryllium disease

Brian L. Scott , T. Mark McCleskey , Anu Chaudhary , Elizabeth Hong-Geller and S. Gnanakaran

Chem. Commun., 2008, 2837-2847

DOI: 10.1039/B718746G
Received 04 Dec 2007, Accepted 28 Feb 2008
First published on the web 09 May 2008

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Chronic beryllium disease (CBD) is a debilitating, incurable, and often fatal disease that is caused by the inhalation of beryllium particulates. The growing use of beryllium in the modern world, in products ranging from computers to dental prosthetics (390 tons of beryllium in the US in the year 2000) necessitates a molecular based understanding of the disease in order to prevent and cure CBD. We have investigated the molecular basis of CBD at Los Alamos National Laboratory during the past six years, employing a multidisciplinary approach of bioinorganic chemistry and immunology. The results of this work, including speciation, inhalation and dissolution, and immunology will be discussed.

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Brian L. Scott
T. Mark McCleskey
Anu Chaudhary
Elizabeth Hong-Geller
S. Gnanakaran

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Chemical Communications

The bioinorganic chemistry and associated immunology of chronic beryllium disease

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