Issue 14, 2008
From the journal:

Chemical Communications

Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2†‡

Preston A. Chase,a   Titel Jurcaa  and  Douglas W. Stephan§*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave. Windsor, Ontario, Canada
E-mail: dstephan@chem.utoronto.ca

Abstract

The Lewis acidB(C6F5)3 has been found to be an efficient catalyst for the direct hydrogenation of imines and the reductive ring-opening of aziridines with H2 under mild conditions; addition of a bulky phosphine allows for the reduction of protected nitriles.

Graphical abstract: Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2

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Article information

DOI
https://doi.org/10.1039/B718598G
Article type
Communication
Submitted
03 Dec 2007
Accepted
15 Feb 2008
First published
06 Mar 2008

Chem. Commun., 2008, 1701-1703

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Lewis acid-catalyzed hydrogenation: B(C6F5)3-mediated reduction of imines and nitriles with H2

P. A. Chase, T. Jurca and D. W. Stephan, Chem. Commun., 2008, 1701 DOI: 10.1039/B718598G

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