Issue 12, 2008

Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases

Abstract

The chromophores pyrene and bordipyrromethenylbenzene directly linked to the 5-position of uridine are tolerated and recognized as thymine derivatives by DNA polymerases in primer extension experiments.

Graphical abstract: Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases

Supplementary files

Article information

Article type
Communication
Submitted
20 Nov 2007
Accepted
07 Jan 2008
First published
29 Jan 2008

Chem. Commun., 2008, 1443-1445

Nucleotide insertion and bypass synthesis of pyrene- and BODIPY-modified oligonucleotides by DNA polymerases

C. Wanninger-Weiß, F. Di Pasquale, T. Ehrenschwender, A. Marx and H. Wagenknecht, Chem. Commun., 2008, 1443 DOI: 10.1039/B718002K

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