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Issue 8, 2008
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Sequence dependence of methylation rate enhancement in meta-phenyleneethynylene foldamers

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Abstract

The methylation rates of a meta-phenyleneethynylene (mPE) oligomer with a terminally-attached 4-dimethylaminopyridine (DMAP) residue are reported for a series of linear and branched methyl sulfonates; these data show that selective methylation is enhanced by locating the DMAP unit at the midpoint of the sequence, allowing the foldamer cavity to function as a reactive sieve.

Graphical abstract: Sequence dependence of methylation rate enhancement in meta-phenyleneethynylene foldamers

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Publication details

The article was received on 18 Oct 2007, accepted on 03 Dec 2007 and first published on 03 Jan 2008


Article type: Communication
DOI: 10.1039/B716122K
Citation: Chem. Commun., 2008,0, 1011-1013
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    Sequence dependence of methylation rate enhancement in meta-phenyleneethynylene foldamers

    R. A. Smaldone and J. S. Moore, Chem. Commun., 2008, 0, 1011
    DOI: 10.1039/B716122K

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