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Issue 32, 2008
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Chemoenzymatic acylation of aminoglycoside antibiotics

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Abstract

The chemoenzymatic installation of the clinically valuable (S)-4-amino-2-hydroxybutyryl side chain onto a number of 2-deoxystreptamine-containing aminoglycosides is described using the purified Bacillus circulans biosynthetic enzymes BtrH and BtrG in combination with a synthetic acyl-SNAC surrogate substrate.

Graphical abstract: Chemoenzymatic acylation of aminoglycoside antibiotics

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Publication details

The article was received on 08 Feb 2008, accepted on 15 May 2008 and first published on 20 Jun 2008


Article type: Communication
DOI: 10.1039/B802248H
Citation: Chem. Commun., 2008,0, 3786-3788
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    Chemoenzymatic acylation of aminoglycoside antibiotics

    N. M. Llewellyn and J. B. Spencer, Chem. Commun., 2008, 0, 3786
    DOI: 10.1039/B802248H

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