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Issue 4, 2008
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Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry

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Abstract

N-Myristoyl transferase-mediated modification with azide-bearing substrates is introduced as a highly selective and practical method for in vitro and in vivo N-terminal labelling of a recombinant protein using bioorthogonal ligation chemistry.

Graphical abstract: Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry

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Publication details

The article was received on 18 Oct 2007, accepted on 05 Nov 2007, published on 13 Nov 2007 and first published online on 13 Nov 2007


Article type: Communication
DOI: 10.1039/B716115H
Citation: Chem. Commun., 2008, 480-482
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    Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry

    W. P. Heal, S. R. Wickramasinghe, P. W. Bowyer, A. A. Holder, D. F. Smith, R. J. Leatherbarrow and E. W. Tate, Chem. Commun., 2008, 480
    DOI: 10.1039/B716115H

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