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Issue 2, 2008
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Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

Merja A. Neukamm,a  Antonio Pintoa  and  Nils Metzler-Nolte*a 
Author affiliations

* Corresponding authors

a Lehrstuhl für Anorganische Chemie I - Bioanorganische Chemie, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätstr. 150, Germany
E-mail: nils.metzler-nolte@rub.de

Abstract

A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co2(CO)8 to give the Co2(CO)6–alkyne labeled peptide 2, which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.

Graphical abstract: Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

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Publication details

The article was received on 21 Aug 2007, accepted on 25 Sep 2007 and first published on 22 Oct 2007


Article type: Communication
DOI: 10.1039/B712886J
Citation: Chem. Commun., 2008,0, 232-234
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    Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

    M. A. Neukamm, A. Pinto and N. Metzler-Nolte, Chem. Commun., 2008, 0, 232
    DOI: 10.1039/B712886J

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