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Issue 3, 2007
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Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach

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Abstract

We review the specific adhesion between ligand-containing vesicles and receptor-functionalized substrates as an established model system used to study the cell recognition process and its control mechanisms. In order to provide better understanding of the underlying physics and to allow for quantitative exploitation of this system, we develop a simple theoretical framework that accounts for the equilibrium state of adhesion and successfully merges the macroscopic and microscopic aspects of the problem. Several mechanisms that are used to control adhesion or induce de-adhesion are studied on the same level of theory. Specifically, the repelling properties of adhesive molecules, the role of repelling molecules, the action of antagonists for a specific binder as well as the influence of an externally applied force are addressed independently within the same formalism.

Graphical abstract: Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach

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Publication details

The article was received on 17 Aug 2006, accepted on 24 Oct 2006 and first published on 08 Dec 2006


Article type: Review Article
DOI: 10.1039/B611892E
Citation: Soft Matter, 2007,3, 275-289
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    Vesicles as a model for controlled (de-)adhesion of cells: a thermodynamic approach

    A. Smith and U. Seifert, Soft Matter, 2007, 3, 275
    DOI: 10.1039/B611892E

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