Jump to main content
Jump to site search

Issue 24, 2007
Previous Article Next Article

Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

Author affiliations

Abstract

Pericosines A–E 15 have been isolated from a strain of Periconia byssoides originally separated from the sea hare Aplysia kurodai. Among them, pericosines C 3 and E 5 were separated as enantiomeric mixtures. Their stereostructures, except for compound 1, have been elucidated or identified on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, and X-ray analysis. In addition, conformation for all the compounds has been discussed. Compounds 13 exhibited significant growth inhibition against tumour cell lines. Pericosine A 1 also showed significant in vivo tumour inhibitory activity. In addition, compound 1 inhibited the protein kinaseEGFR and topoisomerase II.

Graphical abstract: Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Aug 2007, accepted on 08 Oct 2007 and first published on 26 Oct 2007


Article type: Paper
DOI: 10.1039/B713060K
Citation: Org. Biomol. Chem., 2007,5, 3979-3986
  •   Request permissions

    Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities

    T. Yamada, M. Iritani, H. Ohishi, K. Tanaka, K. Minoura, M. Doi and A. Numata, Org. Biomol. Chem., 2007, 5, 3979
    DOI: 10.1039/B713060K

Search articles by author

Spotlight

Advertisements