Issue 22, 2007
From the journal:

Organic & Biomolecular Chemistry

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1†

Jeffery J. Newsome,a   Marie A. Colucci,b   Mary Hassani,c   Howard D. Beallc  and  Christopher J. Moody*ab  

* Corresponding authors

a Department of Chemistry, University of Exeter, Stocker Road, Exeter, UK
E-mail: c.j.moody@nottingham.ac.uk
Fax: +44 115 951 3564

b School of Chemistry, University of Nottingham, University Park, Nottingham, UK

c Department of Biomedical and Pharmaceutical Sciences, The University of Montana, 32 Campus Drive #1552, Missoula, MT, USA

Abstract

A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.

Graphical abstract: Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

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Article information

DOI
https://doi.org/10.1039/B713044A
Article type
Paper
Submitted
24 Aug 2007
Accepted
17 Sep 2007
First published
08 Oct 2007

Org. Biomol. Chem., 2007,5, 3665-3673

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Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

J. J. Newsome, M. A. Colucci, M. Hassani, H. D. Beall and C. J. Moody, Org. Biomol. Chem., 2007, 5, 3665 DOI: 10.1039/B713044A

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