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Issue 22, 2007
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Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

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Abstract

A series of benzimidazole- and benzothiazole-quinones has been synthesized. The ability of these heterocyclic quinones to act as substrates for recombinant human NAD(P)H:quinone oxidoreductase (NQO1), a two-electron reductase upregulated in tumour cells, was determined. Overall, the quinones were excellent substrates for NQO1.

Graphical abstract: Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

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Publication details

The article was received on 24 Aug 2007, accepted on 17 Sep 2007 and first published on 08 Oct 2007


Article type: Paper
DOI: 10.1039/B713044A
Citation: Org. Biomol. Chem., 2007,5, 3665-3673
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    Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

    J. J. Newsome, M. A. Colucci, M. Hassani, H. D. Beall and C. J. Moody, Org. Biomol. Chem., 2007, 5, 3665
    DOI: 10.1039/B713044A

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