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Issue 16, 2007
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Nicotinamide adenine dinucleotide: beyond a redox coenzyme

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Abstract

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)transferases (ARTs), NAD+-dependent deacetylases (sirtuins), tRNA 2′-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

Graphical abstract: Nicotinamide adenine dinucleotide: beyond a redox coenzyme

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Publication details

The article was received on 08 May 2007 and first published on 25 Jun 2007


Article type: Perspective
DOI: 10.1039/B706887E
Citation: Org. Biomol. Chem., 2007,5, 2541-2554
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    Nicotinamide adenine dinucleotide: beyond a redox coenzyme

    H. Lin, Org. Biomol. Chem., 2007, 5, 2541
    DOI: 10.1039/B706887E

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