Nicotinamide adenine dinucleotide: beyond a redox coenzyme

Hening Lin

doi:10.1039/B706887E

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Organic & Biomolecular Chemistry

Issue 16, 2007

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Nicotinamide adenine dinucleotide: beyond a redox coenzyme

Hening Lin

Org. Biomol. Chem., 2007, 5, 2541-2554

DOI: 10.1039/B706887E
Received 08 May 2007, First published on the web 25 Jun 2007

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ADP-ribosylation using nicotinamide adenine dinucleotide (NAD⁺) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)transferases (ARTs), NAD⁺-dependent deacetylases (sirtuins), tRNA 2′-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

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Organic & Biomolecular Chemistry

Nicotinamide adenine dinucleotide: beyond a redox coenzyme

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