Issue 16, 2007
From the journal:

Organic & Biomolecular Chemistry

Nicotinamide adenine dinucleotide: beyond a redox coenzyme

Hening Lin*a  

* Corresponding authors

a Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853
E-mail: hl379@cornell.edu
Fax: +1 607-255-1903
Tel: +1 607-255-4650

Abstract

ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)transferases (ARTs), NAD+-dependent deacetylases (sirtuins), tRNA 2′-phosphotransferases, and ADP-ribosyl cyclases (CD38 and CD157). Focus is given to the enzymatic reactions, mechanisms, structures, and biological functions.

Graphical abstract: Nicotinamide adenine dinucleotide: beyond a redox coenzyme

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Article information

DOI
https://doi.org/10.1039/B706887E
Article type
Perspective
Submitted
08 May 2007
First published
25 Jun 2007

Org. Biomol. Chem., 2007,5, 2541-2554

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Nicotinamide adenine dinucleotide: beyond a redox coenzyme

H. Lin, Org. Biomol. Chem., 2007, 5, 2541 DOI: 10.1039/B706887E

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