Issue 14, 2007

Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

Abstract

The synthesis of a variety of arabinose derivatives that have been modified at C-5 was achieved from D-arabinose. The 5-fluoro and 5-methoxy compounds were converted into the corresponding farnesyl phosphodiesters as putative chain terminators of mycobacterial arabinan biosynthesis. Biological testing of these materials revealed no effective anti-mycobacterial activity.

Graphical abstract: Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

Article information

Article type
Paper
Submitted
29 Mar 2007
Accepted
21 May 2007
First published
08 Jun 2007

Org. Biomol. Chem., 2007,5, 2257-2266

Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

I. A. Smellie, S. Bhakta, E. Sim and A. J. Fairbanks, Org. Biomol. Chem., 2007, 5, 2257 DOI: 10.1039/B704788F

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