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Issue 14, 2007
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Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

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Abstract

The synthesis of a variety of arabinose derivatives that have been modified at C-5 was achieved from D-arabinose. The 5-fluoro and 5-methoxy compounds were converted into the corresponding farnesyl phosphodiesters as putative chain terminators of mycobacterial arabinan biosynthesis. Biological testing of these materials revealed no effective anti-mycobacterial activity.

Graphical abstract: Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

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Publication details

The article was received on 29 Mar 2007, accepted on 21 May 2007 and first published on 08 Jun 2007


Article type: Paper
DOI: 10.1039/B704788F
Citation: Org. Biomol. Chem., 2007,5, 2257-2266
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    Synthesis of putative chain terminators of mycobacterial arabinan biosynthesis

    I. A. Smellie, S. Bhakta, E. Sim and A. J. Fairbanks, Org. Biomol. Chem., 2007, 5, 2257
    DOI: 10.1039/B704788F

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