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Issue 13, 2007
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Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes

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Abstract

Rare earth metal-based enantioselective catalysts that can promote practical cyanation reactions of ketones and ketoimines were developed. These catalytic enantioselective tetrasubstituted carbon-forming reactions are useful platforms for the synthesis of biologically active compounds. ESI-MS and crystallographic studies of the asymmetric catalysts revealed that the active catalysts are polymetallic complexes produced through the assembly of modules. The higher-order structure of the polymetallic complexes has strong effects on catalyst activity and enantioselectivity. Controlling the higher-order structure of artificial polymetallic asymmetric catalysts is a new strategy for optimizing asymmetric catalysts. Recent progress in this approach is also described.

Graphical abstract: Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes

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Publication details

The article was received on 27 Mar 2007 and first published on 10 May 2007


Article type: Perspective
DOI: 10.1039/B704542E
Citation: Org. Biomol. Chem., 2007,5, 2027-2039
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    Catalytic enantioselective construction of tetrasubstituted carbons by self-assembled poly rare earth metal complexes

    M. Shibasaki and M. Kanai, Org. Biomol. Chem., 2007, 5, 2027
    DOI: 10.1039/B704542E

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