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Issue 8, 2007
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Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

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Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate 4. Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.

Graphical abstract: Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

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The article was received on 09 Jan 2007, accepted on 14 Feb 2007 and first published on 01 Mar 2007

Article type: Communication
DOI: 10.1039/B700321H
Citation: Org. Biomol. Chem., 2007,5, 1164-1166
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    Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

    W. Huang, M. J. Miller, E. De Clercq and J. Balzarini, Org. Biomol. Chem., 2007, 5, 1164
    DOI: 10.1039/B700321H

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