Conditions are reported for the facile, one-pot synthesis of α,β-unsaturated ketones via the palladium-catalysed cross-coupling of acyl chlorides with hydrozirconated acetylenes, and its use in the 2-step synthesis of D-5-O-benzyl deoxyxylulose.
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Acyl palladium species in synthesis: single-step synthesis of α,β-unsaturated ketones from acid chlorides
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School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK
E-mail: r.j.cox@bris.ac.uk ;
Fax: +44 (0)117 9298611
E-mail: r.j.cox@bris.ac.uk ;
Fax: +44 (0)117 9298611
Org. Biomol. Chem., 2007,5, 229-232
DOI: 10.1039/B616582F
Received 13 Nov 2006, Accepted 24 Nov 2006
First published online 05 Dec 2006
Organic & Biomolecular Chemistry
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Experimental procedures and data for all synthetic compounds
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