Photochemical control of biological processes

Douglas D. Young; Alexander Deiters

doi:10.1039/B616410M

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Organic & Biomolecular Chemistry

Issue 7, 2007

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Photochemical control of biological processes

Douglas D. Young and Alexander Deiters

Org. Biomol. Chem., 2007, 5, 999-1005

DOI: 10.1039/B616410M
Received 09 Nov 2006, Accepted 07 Dec 2006
First published on the web 20 Dec 2006

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Photochemical regulation of biological processes offers a high level of control to study intracellular mechanisms with unprecedented spatial and temporal resolution. This report summarizes the advances made in recent years, focusing predominantly on the in vivo regulation of gene function using irradiation with UV light. The majority of the described applications entail the utilization of photocaging groups installed either on a small molecule modulator of biomolecular function or directly on a biological macromolecule itself.

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