The first enantioselective synthesis of C3 fluoro-MEP is herein reported. The synthetic pathway developed takes advantage of a selective hydrofluorination of a 2,3-epoxy-1-alcohol to introduce the required tertiary fluoride unit.
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Enantioselective synthesis of C3 fluoro-MEP
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a
School of Life Sciences, University of Dundee, UK
b
WestCHEM, Department of Chemistry, University of Glasgow, Glasgow, UK
E-mail: r.marquez@chem.gla.ac.uk ;
Fax: +44 (0)141 330 4888 ;
Tel: +44 (0)141 330 8491
E-mail: r.marquez@chem.gla.ac.uk ;
Fax: +44 (0)141 330 4888 ;
Tel: +44 (0)141 330 8491
Org. Biomol. Chem., 2007,5, 97-102
DOI: 10.1039/B613656G
Received 19 Sep 2006, Accepted 20 Oct 2006
First published online 10 Nov 2006
Organic & Biomolecular Chemistry
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