Synthesis of protein–polymer conjugates

Karina L. Heredia; Heather D. Maynard

doi:10.1039/B612355D

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Organic & Biomolecular Chemistry

Issue 1, 2007

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Synthesis of protein–polymer conjugates

Karina L. Heredia and Heather D. Maynard

Org. Biomol. Chem., 2007, 5, 45-53

DOI: 10.1039/B612355D
Received 29 Aug 2006, Accepted 12 Oct 2006
First published on the web 08 Nov 2006

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Protein–polymer conjugates are widely employed for applications in medicine, biotechnology and nanotechnology. Covalent attachment of synthetic polymers to proteins improves protein stability, solubility, and biocompatibility. Furthermore, synthetic polymers impart new properties such as self assembly and phase behavior. Polymer attachment at amino acid side-chains and at ligand binding sites is typically exploited. This Emerging Area focuses on synthetic methods to prepare protein-reactive polymers and also employing the protein itself as an initiator for polymerization.

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Organic & Biomolecular Chemistry

Synthesis of protein–polymer conjugates

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