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Utilization of achiral alkenyl amines for the preparation of high affinity Grb2 SH2 domain-binding macrocycles by ring-closing metathesis

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a
Laboratory of Medicinal Chemistry, Bldg. 376 Boyles St., Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, USA
E-mail: tburke@helix.nih.gov;
Fax: 301-846-6033 ;
Tel: 301-846-5906
b
Protein Chemistry Laboratory, Bldg. 469, SAIC-Frederick, Frederick, USA
c
Urologic Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA
Org. Biomol. Chem., 2007,5, 367-372

DOI: 10.1039/B611887A
Received 17 Aug 2006, Accepted 28 Sep 2006
First published online 04 Dec 2006
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