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Issue 1, 2007
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A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

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Abstract

A highly effective one-pot Friedländer quinoline synthesis using inexpensive reagents has been developed. o-Nitroarylcarbaldehydes were reduced to o-aminoarylcarbaldehydes with iron in the presence of catalytic HCl (aq.) and subsequently condensed in situ with aldehydes or ketones to form mono- or di-substituted quinolines in high yields (66–100%).

Graphical abstract: A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

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Publication details

The article was received on 21 Sep 2006, accepted on 25 Oct 2006 and first published on 06 Nov 2006


Article type: Communication
DOI: 10.1039/B613775J
Citation: Org. Biomol. Chem., 2007,5, 61-64
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    A highly effective one-pot synthesis of quinolines from o-nitroarylcarbaldehydes

    A. Li, E. Ahmed, X. Chen, M. Cox, A. P. Crew, H. Dong, M. Jin, L. Ma, B. Panicker, K. W. Siu, A. G. Steinig, K. M. Stolz, P. A. R. Tavares, B. Volk, Q. Weng, D. Werner and M. J. Mulvihill, Org. Biomol. Chem., 2007, 5, 61
    DOI: 10.1039/B613775J

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