Colloidal ZnSe nanocrystals (NCs) exhibit size-dependent fluorescence in the wavelength range of 350–450 nm, making them promising emitters for optoelectronic devices in the blue/near UV region. This Perspective review gives an overview of the chemical synthesis methods developed for size- and shape-controlled ZnSe NCs as well as for related core/shell and alloy structures. Special emphasis is put on the discussion of the optical and structural properties of the obtained nanostructures. Finally, the use of ZnSe as a host material for magnetic or luminescent dopant ions is highlighted.