Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

Céline Deraeve; Marguerite Pitié; Honoré Mazarguil; Bernard Meunier

doi:10.1039/B616085A

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New Journal of Chemistry

Issue 2, 2007

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Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

Céline Deraeve , Marguerite Pitié , Honoré Mazarguil and Bernard Meunier

New J. Chem., 2007, 31, 193-195

DOI: 10.1039/B616085A
Received 06 Nov 2006, Accepted 19 Dec 2006
First published on the web 09 Jan 2007

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Abstract
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A strategy based on the use of a tetradentate ligand containing two linked 8-hydroxyquinolines allowed a significant increase in the ability to protect against β-amyloid peptide precipitation in the presence of Cu(II), Zn(II) and Fe(III) when compared to clioquinol, a 8-hydroxyquinoline derivative active in vivo.

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Expected complexes, protocols and solubility of Aβ _1-42 for different ratios of Cu(II).
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New Journal of Chemistry

Bis-8-hydroxyquinoline ligands as potential anti-Alzheimer agents

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