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Issue 10, 2007
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Proteins at membrane surfaces—a review of approaches

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Membrane proteins are critical for normal cellular differentiation and function, and alterations in these proteins often leads to cell dysfunction and disease. Membrane proteomics aims to identify the membrane protein constituents, their posttranslational modifications, proteinprotein interactions, and dynamics. Efforts to identify membrane proteins and elucidate their dynamics have been plagued by the challenges presented by studying water insoluble proteins that are distributed among a range of membranes in a cell and often occur at a relatively low abundance. This brief review presents a summary of the literature related to membrane proteomics with an emphasis on efforts to develop effective protocols for the enrichment of membrane proteins, particularly those located in the plasma membrane.

Graphical abstract: Proteins at membrane surfaces—a review of approaches

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The article was received on 12 Jun 2007, accepted on 04 Jul 2007 and first published on 21 Aug 2007

Article type: Review Article
DOI: 10.1039/B708581H
Citation: Mol. BioSyst., 2007,3, 705-713
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    Proteins at membrane surfaces—a review of approaches

    B. A. Macher and T. Yen, Mol. BioSyst., 2007, 3, 705
    DOI: 10.1039/B708581H

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