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Issue 7, 2007
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Inhibition of lysine biosynthesis: an evolving antibiotic strategy

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Abstract

Bacterial biosynthesis of lysine has come under increased scrutiny as a target for novel antibacterial agents as it provides lysine for protein synthesis and both lysine and meso-diaminopimelate for construction of the bacterial peptidoglycancell wall. In this Highlight article we review recent advances in the validation of antibiotic targets, studies of the enzymes of the lysine biosynthetic pathway and development of inhibitors of these enzymes.

Graphical abstract: Inhibition of lysine biosynthesis: an evolving antibiotic strategy

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Publication details

The article was first published on 23 May 2007


Article type: Highlight
DOI: 10.1039/B705624A
Citation: Mol. BioSyst., 2007,3, 458-465
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    Inhibition of lysine biosynthesis: an evolving antibiotic strategy

    C. A. Hutton, M. A. Perugini and J. A. Gerrard, Mol. BioSyst., 2007, 3, 458
    DOI: 10.1039/B705624A

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