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Issue 9, 2007
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Communication between the cytoskeleton and the nuclear envelope to position the nucleus

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Abstract

In most eukaryotic cells, the nucleus is localized to a specific location. This highlight article focuses on recent advances describing the mechanisms of nuclear migration and anchorage. Central to nuclear positioning mechanisms is the communication between the nuclear envelope and the cytoskeleton. All three components of the cytoskeletonmicrotubules, actin filaments and intermediate filaments—are involved in nuclear positioning to varying degrees in different cell types. KASH proteins on the outer nuclear membrane connect to SUN proteins on the inner nuclear membrane. Together they transfer forces between the cytoskeleton and the nuclear lamina. Once at the outer nuclear membrane, KASH proteins can interact with the cytoskeleton. Nuclear migrations are a component of many cellular migration events and defects in nuclear positioning lead to human diseases, most notably lissencephaly.

Graphical abstract: Communication between the cytoskeleton and the nuclear envelope to position the nucleus

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Publication details

The article was first published on 16 Jul 2007


Article type: Highlight
DOI: 10.1039/B703878J
Citation: Mol. BioSyst., 2007,3, 583-589
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    Communication between the cytoskeleton and the nuclear envelope to position the nucleus

    D. A. Starr, Mol. BioSyst., 2007, 3, 583
    DOI: 10.1039/B703878J

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