Issue 1, 2007

Controlling influenza virus replication by inhibiting its proton channel

Abstract

Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.

Graphical abstract: Controlling influenza virus replication by inhibiting its proton channel

Article information

Article type
Highlight
Submitted
10 Aug 2006
Accepted
20 Oct 2006
First published
22 Nov 2006

Mol. BioSyst., 2007,3, 18-23

Controlling influenza virus replication by inhibiting its proton channel

L. H. Pinto and R. A. Lamb, Mol. BioSyst., 2007, 3, 18 DOI: 10.1039/B611613M

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