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Issue 1, 2007
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Controlling influenza virus replication by inhibiting its proton channel

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Abstract

Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.

Graphical abstract: Controlling influenza virus replication by inhibiting its proton channel

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Publication details

The article was received on 10 Aug 2006, accepted on 20 Oct 2006 and first published on 22 Nov 2006


Article type: Highlight
DOI: 10.1039/B611613M
Citation: Mol. BioSyst., 2007,3, 18-23
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    Controlling influenza virus replication by inhibiting its proton channel

    L. H. Pinto and R. A. Lamb, Mol. BioSyst., 2007, 3, 18
    DOI: 10.1039/B611613M

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