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Issue 11, 2007
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Intelligent routes to the controlled synthesis of nanoparticles

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We describe an autonomous ‘black-box’ system for the controlled synthesis of fluorescent nanoparticles. The system uses a microfluidic reactor to carry out the synthesis and an in-line spectrometer to monitor the emission spectra of the emergent particles. The acquired data is fed into a control algorithm which reduces each spectrum to a scalar ‘dissatisfaction coefficient’ and then intelligently updates the reaction conditions in an effort to minimise this coefficient and so drive the system towards a desired goal. In the tests reported here, CdSe nanoparticles were prepared by separately injecting solutions of CdO and Se into the two inlets of a heated y-shaped microfluidic reactor. A noise-tolerant global search algorithm was then used to efficiently identify—without any human intervention—the injection rates and temperature that yielded the optimum intensity for a chosen emission wavelength.

Graphical abstract: Intelligent routes to the controlled synthesis of nanoparticles

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The article was received on 25 Jul 2007, accepted on 03 Aug 2007 and first published on 15 Aug 2007

Article type: Paper
DOI: 10.1039/B711412E
Citation: Lab Chip, 2007,7, 1434-1441
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    Intelligent routes to the controlled synthesis of nanoparticles

    S. Krishnadasan, R. J. C. Brown, A. J. deMello and J. C. deMello, Lab Chip, 2007, 7, 1434
    DOI: 10.1039/B711412E

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