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Issue 10, 2007
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Micro pumping with cardiomyocyte–polymer hybrid

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Abstract

This paper presents a hybrid micropump actuated by the up–down motion of a dome shaped cell-polymer membrane composite. The contractile force induced from self-beating cardiomyocytes cultured on the membrane causes shrinkage and relaxation of a microchamber, leading to a flow in a microchannel. Flow direction is controlled by the geometry of diffuser/nozzle in the microchannel. The fabrication process is noninvasive to cells, thus, cardiomyocytes can robustly maintain their activity for a long time. The fluid motion in the microchannel was monitored by tracking 2 µm polystyrene beads. A net flow rate of 0.226 nl min−1 was obtained in our microscale device. Our device demonstrates a unique performance of a cell–microdevice hybrid lab-on-a-chip that does not require any external power source, preventing electrical or heat shock to analytes.

Graphical abstract: Micro pumping with cardiomyocyte–polymer hybrid

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Publication details

The article was received on 15 Mar 2007, accepted on 06 Jun 2007 and first published on 20 Jul 2007


Article type: Technical Note
DOI: 10.1039/B703900J
Citation: Lab Chip, 2007,7, 1367-1370
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    Micro pumping with cardiomyocyte–polymer hybrid

    J. Park, I. C. Kim, J. Baek, M. Cha, J. Kim, S. Park, J. Lee and B. Kim, Lab Chip, 2007, 7, 1367
    DOI: 10.1039/B703900J

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