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Issue 4, 2007
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On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging

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Abstract

This paper presents a new manufacturing method to generate monodisperse microbubble contrast agents with polydispersity index (σ) values of <2% through microfluidic flow-focusing. Micron-sized lipid shell-based perfluorocarbon (PFC) gas microbubbles for use as ultrasound contrast agents were produced using this method. The poly(dimethylsiloxane) (PDMS)-based devices feature expanding nozzle geometry with a 7 μm orifice width, and are robust enough for consistent production of microbubbles with runtimes lasting several hours. With high-speed imaging, we characterized relationships between channel geometry, liquid flow rate Q, and gas pressure P in controlling bubble sizes. By a simple optimization of the channel geometry and Q and P, bubbles with a mean diameter of <5 μm can be obtained, ideal for various ultrasonic imaging applications. This method demonstrates the potential of microfluidics as an efficient means for custom-designing ultrasound contrast agents with precise size distributions, different gas compositions and new shell materials for stabilization, and for future targeted imaging and therapeutic applications.

Graphical abstract: On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging

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Publication details

The article was received on 29 Sep 2006, accepted on 06 Feb 2007 and first published on 08 Mar 2007


Article type: Paper
DOI: 10.1039/B701481N
Citation: Lab Chip, 2007,7, 463-468
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    On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging

    K. Hettiarachchi, E. Talu, M. L. Longo, P. A. Dayton and A. P. Lee, Lab Chip, 2007, 7, 463
    DOI: 10.1039/B701481N

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