A microfluidic device based on droplet storage for screening solubility diagrams

Philippe Laval; Nicolas Lisai; Jean-Baptiste Salmon; Mathieu Joanicot

doi:10.1039/B700799J

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Lab on a Chip

Issue 7, 2007

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A microfluidic device based on droplet storage for screening solubility diagrams

Philippe Laval , Nicolas Lisai , Jean-Baptiste Salmon and Mathieu Joanicot

Lab Chip, 2007, 7, 829-834

DOI: 10.1039/B700799J
Received 18 Jan 2007, Accepted 02 Apr 2007
First published on the web 20 Apr 2007

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Abstract
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This work describes a new microfluidic device developed for the rapid screening of solubility diagrams. In several parallel channels, hundreds of nanolitre volume droplets of a given solution are first stored with a gradual variation in the solute concentration. Then, the application of a temperature gradient along these channels enables us to read directly and quantitatively phase diagrams, concentration vs. temperature. We show, using a solution of adipic acid, that we can measure ten points of the solubility curve in less than 1 hr and with only 250 µL of solution.

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