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Issue 7, 2007
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Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation

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Abstract

We have developed a biological micro-electromechanical system (Bio-MEMS) device consisting of surface-modified microfabricated silicon cantilevers and an AFM detection apparatus for the study of cultured myotubes. With this system we are able to selectively stimulate the myotubes as well as report on a variety of physiological properties of the myotubes in real time and in a high-throughput manner. This system will serve as the foundation for future work integrating multiple tissue types for the creation of Bio-MEMS analogues of complex tissues and biological circuits.

Graphical abstract: Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation

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Publication details

The article was received on 08 Dec 2006, accepted on 27 Mar 2007 and first published on 20 Apr 2007


Article type: Technical Note
DOI: 10.1039/B617939H
Citation: Lab Chip, 2007,7, 920-922
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    Integration of functional myotubes with a Bio-MEMS device for non-invasive interrogation

    K. Wilson, P. Molnar and J. Hickman, Lab Chip, 2007, 7, 920
    DOI: 10.1039/B617939H

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