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A novel 3D mammalian cell perfusion-culture system in microfluidic channels

Yi-Chin Toh,ab   Chi Zhang,ab   Jing Zhang,a   Yuet Mei Khong,ab   Shi Chang,c   Victor D. Samper,a   Danny van Noort,a   Dietmar W. Hutmacherbgh and   Hanry Yu*abcdef  
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Corresponding authors
a
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore
E-mail: hyu@ibn.a-star.edu.sg, nmiyuh@nus.edu.sg;
Fax: +65-6516 8261 ;
Tel: +65-6516 3466
b
NUS Graduate Programme in Bioengineering, NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore
c
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
d
Singapore-MIT Alliance, E4-04-10, 4 Engineering Drive 3, Singapore
e
NUS Tissue-Engineering Programme, DSO Labs, National University of Singapore, Singapore
f
Department of Haematology-Oncology, National University Hospital, Singapore
g
Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore
h
Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Lab Chip, 2007,7, 302-309

DOI: 10.1039/B614872G
Received 16 Oct 2006, Accepted 21 Dec 2006
First published online 23 Jan 2007
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