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Issue 7, 2007
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Surface modification of thermoplastics—towards the plastic biochip for high throughput screening devices

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Abstract

Microarrays have become one of the most convenient tools for high throughput screening, supporting major advances in genomics and proteomics. Other important applications can be found in medical diagnostics, detection of biothreats, drug discovery, etc. Integration of microarrays with microfluidic devices can be highly advantageous in terms of portability, shorter analysis time and lower consumption of expensive biological analytes. Since fabrication of microfluidic devices using traditional materials such as glass is rather expensive, there is great interest in employing polymeric materials as a low cost alternative that is suitable for mass production. A number of commercially available plastic materials were reviewed for this purpose and poly(methylmethacrylate) Zeonor 1060R and Zeonex E48R were identified as promising candidates, for which methods for surface modification and covalent immobilization of DNA oligonucleotides were developed. In addition, we present proof-of-concept plastic-based microarrays with and without integration with microfluidics.

Graphical abstract: Surface modification of thermoplastics—towards the plastic biochip for high throughput screening devices

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Publication details

The article was received on 12 Jan 2007, accepted on 11 Apr 2007 and first published on 02 May 2007


Article type: Paper
DOI: 10.1039/B700322F
Citation: Lab Chip, 2007,7, 856-862
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    Surface modification of thermoplastics—towards the plastic biochip for high throughput screening devices

    G. A. Diaz-Quijada, R. Peytavi, A. Nantel, E. Roy, M. G. Bergeron, M. M. Dumoulin and T. Veres, Lab Chip, 2007, 7, 856
    DOI: 10.1039/B700322F

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