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Issue 46, 2007
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Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

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Abstract

Gd-doped iron oxide nanoparticles were developed for use in tumour therapy via magnetic fluid hyperthermia (MFH). The nanoparticle composition was Gd0.02Fe2.98O4 as determined by ICP-AES. TEM image analysis showed the primary particles to be about 13 nm in diameter. The specific power adsorption rate (SAR) determined with a field strength of 246 Oe and 52 kHz was 36 W per gram of Fe. This value is about 4 times higher than the reported SAR values for Fe3O4. The heating rate for the nanoparticles in vivo and the potential for tumour therapy were determined in a mouse model. The mouse models treated with doped iron oxide displayed much slower tumour growth, the tumour doubled its mass after 7 days post-treatment compared to 4 days for those models treated with standard iron oxide or saline solution.

Graphical abstract: Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

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Publication details

The article was received on 06 Aug 2007, accepted on 04 Oct 2007 and first published on 16 Oct 2007


Article type: Paper
DOI: 10.1039/B711962C
Citation: J. Mater. Chem., 2007,17, 4914-4918
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    Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

    P. Drake, H. Cho, P. Shih, C. Kao, K. Lee, C. Kuo, X. Lin and Y. Lin, J. Mater. Chem., 2007, 17, 4914
    DOI: 10.1039/B711962C

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