Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

Philip Drake; Hui-Ju Cho; Pei-Shin Shih; Chao-Hung Kao; Kun-Feng Lee; Chien-Hung Kuo; Xi-Zhang Lin; Yuh-Jiuan Lin

doi:10.1039/B711962C

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Journal of Materials Chemistry

Issue 46, 2007

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Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

Philip Drake , Hui-Ju Cho , Pei-Shin Shih , Chao-Hung Kao , Kun-Feng Lee , Chien-Hung Kuo , Xi-Zhang Lin and Yuh-Jiuan Lin

J. Mater. Chem., 2007, 17, 4914-4918

DOI: 10.1039/B711962C
Received 06 Aug 2007, Accepted 04 Oct 2007
First published on the web 16 Oct 2007

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Gd-doped iron oxide nanoparticles were developed for use in tumour therapy via magnetic fluid hyperthermia (MFH). The nanoparticle composition was Gd_0.02Fe_2.98O₄ as determined by ICP-AES. TEM image analysis showed the primary particles to be about 13 nm in diameter. The specific power adsorption rate (SAR) determined with a field strength of 246 Oe and 52 kHz was 36 W per gram of Fe. This value is about 4 times higher than the reported SAR values for Fe₃O₄. The heating rate for the nanoparticles in vivo and the potential for tumour therapy were determined in a mouse model. The mouse models treated with doped iron oxide displayed much slower tumour growth, the tumour doubled its mass after 7 days post-treatment compared to 4 days for those models treated with standard iron oxide or saline solution.

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Philip Drake
Hui-Ju Cho
Pei-Shin Shih
Chao-Hung Kao
Kun-Feng Lee
Chien-Hung Kuo
Xi-Zhang Lin
Yuh-Jiuan Lin

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