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Issue 19, 2007
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Formation of giant amphiphiles by post-functionalization of hydrophilic proteinpolymer conjugates

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Abstract

A novel, generic method for the synthesis of families of tri-block proteinpolymer giant amphiphiles was designed and developed. We have synthesized a hydrophilic α-maleimido poly-1-alkyne with Mn = 9.5 kDa (1H-NMR) and narrow PDi (1.15 as measured by SEC) via ATRP (Atom Transfer Radical Polymerization). This polymer was succesfully coupled to BSA to afford a hydrophilic multifunctional bioconjugate which was isolated using protein purification techniques and fully characterized. Following the post-functionalization approach, we introduced hydrophobicity to the resulting hydrophilic biohybrid by a straightforward, high yield “click”-chemistry cycloaddition step. The resulting tri-block proteinpolymer amphiphiles were isolated and showed interesting aggregation patterns (TEM, confocal microscopy).

Graphical abstract: Formation of giant amphiphiles by post-functionalization of hydrophilic protein–polymer conjugates

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Publication details

The article was received on 12 Dec 2006, accepted on 28 Feb 2007 and first published on 20 Mar 2007


Article type: Paper
DOI: 10.1039/B618079E
Citation: J. Mater. Chem., 2007,17, 1916-1922
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    Formation of giant amphiphiles by post-functionalization of hydrophilic proteinpolymer conjugates

    B. Le Droumaguet, G. Mantovani, D. M. Haddleton and K. Velonia, J. Mater. Chem., 2007, 17, 1916
    DOI: 10.1039/B618079E

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