Advanced nuclear analytical techniques for metalloproteomics

Yuxi Gao; Chunying Chen; Zhifang Chai

doi:10.1039/B703323K

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Journal of Analytical Atomic Spectrometry

Issue 8, 2007

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Advanced nuclear analytical techniques for metalloproteomics

Yuxi Gao , Chunying Chen and Zhifang Chai

J. Anal. At. Spectrom., 2007, 22, 856-866

DOI: 10.1039/B703323K
Received 05 Mar 2007, Accepted 01 Jun 2007
First published on the web 26 Jun 2007
This article is part of the collection: Metallomics

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Abstract
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Metalloproteomics is an emerging scientific field. It is focused to investigate the distributions and compositions of all metalloproteins in a proteome, their structural and functional characterization and their structural metal-binding moieties. Various nuclear analytical techniques, such as neutron activation analysis, X-ray fluorescence, isotope tracer, Mössbauer spectrometry, X-ray absorption spectrometry and neutron scattering and diffraction, are powerful tools to study a number of the basic issues in metalloproteomics. In this paper, the applications of the advanced nuclear techniques in this field are selectively outlined, along with their advantages and limitations.

Abstract from Analytical Abstracts 2008

Metalloproteomics is an emerging scientific field. It is focused to investigate the distributions and compositions of all metalloproteins in a proteome, their structural and functional characterization and their structural metal-binding moieties. Various nuclear analytical techniques, such as neutron activation analysis, X-ray fluorescence, isotope tracer, Mossbauer spectrometry, X-ray absorption spectrometry and neutron scattering and diffraction, are powerful tools to study a number of the basic issues in metalloproteomics. In this paper, the applications of the advanced nuclear techniques in this field are selectively outlined, along with their advantages and limitations. (127 references).

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