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Issue 11, 2007
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Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

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Abstract

The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N,N-dimethyl-N-(2-hydroxyethyl)ammonium (choline derivatives) and alkyl-triethylammonium salts towards HeLa cells has been studied. The relative toxicities have been determined in the presence and absence of foetal bovine serum using an MTT assay after 24 and 48 h, and attempts to determine possible sources of the observed toxicity investigated using microscopy and by measuring the intracellular calcium concentration, presence of reactive oxygen species and mitochondrial membrane potential in cells exposed to 1-ethyl-3-methylimidazolium tetrafluoroborate.

Graphical abstract: Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

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Publication details

The article was received on 26 Mar 2007, accepted on 19 Jul 2007 and first published on 03 Aug 2007


Article type: Paper
DOI: 10.1039/B704503D
Citation: Green Chem., 2007,9, 1191-1197
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    Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

    X. Wang, C. A. Ohlin, Q. Lu, Z. Fei, J. Hu and P. J. Dyson, Green Chem., 2007, 9, 1191
    DOI: 10.1039/B704503D

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