The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy

Andrea F. Armstrong; John F. Valliant

doi:10.1039/B709843J

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Dalton Transactions

Issue 38, 2007

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The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy

Andrea F. Armstrong and John F. Valliant

Dalton Trans., 2007, 4240-4251

DOI: 10.1039/B709843J
Received 28 Jun 2007, Accepted 14 Aug 2007
First published on the web 11 Sep 2007

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The role of carboranes in medicinal chemistry has diversified in recent years and now extends into areas of drug discovery, molecular imaging, and targeted radionuclide therapy. An introduction to carborane chemistry is provided to familiarize the non-expert with some key properties of these molecules, followed by an overview of current medicinally-orientated research involving carboranes. The broad-ranging nature of this research is illustrated, with emphasis placed on recent highlights and advances in this field.

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Dalton Transactions

The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy

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