η1-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

Ian J. S. Fairlamb; Jason M. Lynam; Benjamin E. Moulton; Ian E. Taylor; Anne K. Duhme-Klair; Philip Sawle; Roberto Motterlini

doi:10.1039/B707377A

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Dalton Transactions

Issue 33, 2007

The international journal for inorganic, organometallic and bioinorganic chemistry

Impact Factor 3.838 48 Issues per Year Indexed in MEDLINE

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η¹-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

Ian J. S. Fairlamb,*^a Jason M. Lynam,*^a Benjamin E. Moulton,^a Ian E. Taylor,^a Anne K. Duhme-Klair,^a Philip Sawle^b and Roberto Motterlini*^b

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Department of Chemistry, University of York, Heslington, York, UK
E-mail: ijsf1@york.ac.uk

Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
E-mail: r.motterlini@imperial.ac.uk

Dalton Trans., 2007, 3603-3605

DOI: 10.1039/B707377A
Received 16 May 2007, Accepted 01 Jun 2007
First published online 29 Jun 2007

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An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely [Mo(CO)₃(η⁵-C₅H₅)(η¹-{O}–C{ [double bond, length as m-dash] O}–O–CMeCH-COMeCBr)]BF₄ (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxity and vasodilatory properties of CORM-F10 have been determined.