Developing new metal-based therapeutics: challenges and opportunities

Trevor W. Hambley

doi:10.1039/B706075K

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Dalton Transactions

Issue 43, 2007

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Developing new metal-based therapeutics: challenges and opportunities

Trevor W. Hambley

Dalton Trans., 2007, 4929-4937

DOI: 10.1039/B706075K
Received 23 Apr 2007, Accepted 16 May 2007
First published on the web 04 Oct 2007
This article is part of the collection: Dalton Discussion 10: Applications of metals in medicine and healthcare

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Abstract
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Unexpected side effects and problems experienced in clinical trials have created a difficult environment for those developing new pharmaceuticals and, as a consequence, the number of new chemical entities being registered has fallen to a historic low. Those developing metal-based therapeutics will face the same difficulties, but this environment also provides many opportunities for creative solutions to be applied to overcoming the problems and concerns. In this perspective, these challenges and opportunities are considered in the context of examples of a number of classes of metal-based therapeutics.

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Developing new metal-based therapeutics: challenges and opportunities

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