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Issue 43, 2007
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Metal based drugs: from serendipity to design

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The platinum anticancer drug cisplatin has made a major contribution to the treatment of testicular and ovarian cancer. This chance discovery has been the stimulus for research into other metal-based drugs. Inorganic chemistry offers many opportunities for medicinal chemistry, and the discovery of metal-based drugs has moved on from chance discovery to rational drug design. There are however, many challenges associated with the drug discovery and development process. The aim of this review is to provide case histories exemplifying the role of rational drug design in modern inorganic medicinal chemistry in the context of these challenges. The evolution of platinum drugs from cisplatin to third generation drugs is described. The molecular target for the platinum agents is DNA. Alternative molecular targets such as thiol-containing proteins and redox processes are proposed. The example of a simple, safe, efficacious metal-based drug, Fosrenol™, is reviewed.

Graphical abstract: Metal based drugs: from serendipity to design

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Publication details

The article was received on 12 Apr 2007, accepted on 01 Jun 2007 and first published on 19 Sep 2007

Article type: Perspective
DOI: 10.1039/B705551J
Citation: Dalton Trans., 2007,0, 4903-4917
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    Metal based drugs: from serendipity to design

    S. P. Fricker, Dalton Trans., 2007, 0, 4903
    DOI: 10.1039/B705551J

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