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Issue 43, 2007
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Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

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Abstract

New M(II) bis(thiosemicarbazonato) complexes (M = Ni(II), Cu(II) and Zn(II)) featuring allyl groups at the exocyclic nitrogens have been synthesised. The complexes were characterised in solution by spectroscopic methods and their solid state structures determined by single crystal X-ray diffraction using synchrotron radiation. The Zn(II) complex was found to be intrinsically fluorescent and soluble in biocompatible media. The uptake of this Zn(II) complex in HeLa, MCF-7 and IGROV cancer cells was monitored by fluorescence microscopies (epi- and confocal fluorescence imaging). The radiolabelling to 64Cu(II) bis(thiosemicarbazonato) complex was performed cleanly by transmetallation from the corresponding Zn(II) species using 64Cu(OAc)2.

Graphical abstract: Designing Zn(ii) and Cu(ii) derivatives as probes for in vitro fluorescence imaging

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Publication details

The article was received on 05 Apr 2007, accepted on 27 Jun 2007 and first published on 13 Sep 2007


Article type: Paper
DOI: 10.1039/B705227H
Citation: Dalton Trans., 2007,0, 4988-4997
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    Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

    S. I. Pascu, P. A. Waghorn, T. D. Conry, H. M. Betts, J. R. Dilworth, G. C. Churchill, T. Pokrovska, M. Christlieb, F. I. Aigbirhio and J. E. Warren, Dalton Trans., 2007, 0, 4988
    DOI: 10.1039/B705227H

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