Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

Sofia I. Pascu; Philip A. Waghorn; Timothy D. Conry; Helen M. Betts; Jonathan R. Dilworth; Grant C. Churchill; Tzveta Pokrovska; Martin Christlieb; Franklin I. Aigbirhio; John E. Warren

doi:10.1039/B705227H

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Dalton Transactions

Issue 43, 2007

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Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

Sofia I. Pascu , Philip A. Waghorn , Timothy D. Conry , Helen M. Betts , Jonathan R. Dilworth , Grant C. Churchill , Tzveta Pokrovska , Martin Christlieb , Franklin I. Aigbirhio and John E. Warren

Dalton Trans., 2007, 4988-4997

DOI: 10.1039/B705227H
Received 05 Apr 2007, Accepted 27 Jun 2007
First published on the web 13 Sep 2007
This article is part of the collection: Dalton Discussion 10: Applications of metals in medicine and healthcare

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New M(II) bis(thiosemicarbazonato) complexes (M = Ni(II), Cu(II) and Zn(II)) featuring allyl groups at the exocyclic nitrogens have been synthesised. The complexes were characterised in solution by spectroscopic methods and their solid state structures determined by single crystal X-ray diffraction using synchrotron radiation. The Zn(II) complex was found to be intrinsically fluorescent and soluble in biocompatible media. The uptake of this Zn(II) complex in HeLa, MCF-7 and IGROV cancer cells was monitored by fluorescence microscopies (epi- and confocal fluorescence imaging). The radiolabelling to ⁶⁴Cu(II) bis(thiosemicarbazonato) complex was performed cleanly by transmetallation from the corresponding Zn(II) species using ⁶⁴Cu(OAc)₂.

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Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

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