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Issue 43, 2007
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Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles

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Abstract

Platinum(II)-based DNA intercalators where the intercalating ligand is 1,10-phenanthroline or a phenanthroline derivative and where the ancillary ligand is either achiral (e.g. ethylenediamine) or chiral (e.g. diaminocyclohexane) show a range of cytotoxicities with a defined structure–activity relationship. The most cytotoxic are those that contain methylated-phenanthroline ligands and 1S,2S-diaminocyclohexane (S,S-dach) as the ancillary ligand. We have developed a new purification method using Sep-Pak® C-18 reverse phase columns, which means these metal complexes can be made faster and cheaper compared to published methods. Platinum(II)-based complexes containing imidazole, pyrrole and β-alanine subunits, that are capable of recognising specific DNA base-pair sequences have also been synthesised. These include linear or hairpin polyamide ligands that can recognise DNA sequences up to seven base-pairs in length and contain single platinum centres capable of forming monofunctional adducts with DNA. We have now synthesised and characterised, by 1H and 195Pt NMR, ESI-MS and elemental analysis, the first dinuclear platinum(II) DNA sequence selective agent. Finally, using 1H NMR we have examined the encapsulation of our platinum(II)-based DNA intercalators by cucurbit[6]uril (CB[6]). Encapsulation by CB[6] was found to not significantly change the cytotoxicity of five platinum(II)-based DNA intercalators, indicating it may have utility as a molecular carrier for improved drug delivery.

Graphical abstract: Novel platinum(ii)-based anticancer complexes and molecular hosts as their drug delivery vehicles

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Publication details

The article was received on 02 Apr 2007, accepted on 03 May 2007 and first published on 27 Sep 2007


Article type: Paper
DOI: 10.1039/B704973K
Citation: Dalton Trans., 2007,0, 5055-5064
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    Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles

    N. J. Wheate, R. I. Taleb, A. M. Krause-Heuer, R. L. Cook, S. Wang, V. J. Higgins and J. R. Aldrich-Wright, Dalton Trans., 2007, 0, 5055
    DOI: 10.1039/B704973K

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