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Issue 7, 2007
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Regioselective (site-selective) functionalisation of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

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Abstract

This tutorial review focuses on several practical synthetic transformations utilising palladium catalysis that facilitate the synthesis of functionalised unsaturated heterocycles in a regioselective (site-selective) manner. Cross-couplings of electron-deficient, electron-neutral and electron-rich unsaturated halogenated heterocycles with various organometallic reagents, and other types of nucleophiles, are detailed. Direct arylation of electron-rich unsaturated heterocyclic compounds by C–H functionalisation is also presented.

Graphical abstract: Regioselective (site-selective) functionalisation of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

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Publication details

The article was received on 14 Feb 2007 and first published on 27 Apr 2007


Article type: Tutorial Review
DOI: 10.1039/B611177G
Citation: Chem. Soc. Rev., 2007,36, 1036-1045
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    Regioselective (site-selective) functionalisation of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

    I. J. S. Fairlamb, Chem. Soc. Rev., 2007, 36, 1036
    DOI: 10.1039/B611177G

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