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Issue 8, 2007
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Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization

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Abstract

In this tutorial review the process and applications of peptide self-assembly into nanotubes, nanospheres, nanofibrils, nanotapes, and other ordered structures at the nano-scale are discussed. The formation of well-ordered nanostructures by a process of self-association represents the essence of modern nanotechnology. Such self-assembled structures can be formed by a variety of building blocks, both organic and inorganic. Of the organic building blocks, peptides are among the most useful ones. Peptides possess the biocompatibility and chemical diversity that are found in proteins, yet they are much more stable and robust and can be readily synthesized on a large scale. Short peptides can spontaneously associate to form nanotubes, nanospheres, nanofibrils, nanotapes, and other ordered structures at the nano-scale. Peptides can also form macroscopic assemblies such as hydrogels with nano-scale order. The application of peptide building blocks in biosensors, tissue engineering, and the development of antibacterial agents has already been demonstrated.

Graphical abstract: Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization

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Publication details

The article was received on 05 Dec 2006 and first published on 02 May 2007


Article type: Tutorial Review
DOI: 10.1039/B605536M
Citation: Chem. Soc. Rev., 2007,36, 1263-1269
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    Self-assembled peptide nanostructures: the design of molecular building blocks and their technological utilization

    E. Gazit, Chem. Soc. Rev., 2007, 36, 1263
    DOI: 10.1039/B605536M

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