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Issue 4, 2007
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CdSe nanocrystal based chem-/bio- sensors

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Semiconductor nanocrystals (NCs) have found application in biology mostly as optical imaging agents where the photophysical properties of the NCs are insensitive to species in their environment. This tutorial review examines the application of CdSe NCs as optical sensing agents where the NC's photophysical properties are sensitive to species in their environment. For this case, the NC is modified at the surface with a conjugate, which interacts with an external agent by physical (i.e. recognition) or chemical means. Signal transduction in these chem-bio (CB) sensitive NCs is derived primarily from energy transfer between the NC and the external agent, which functions as the energy transfer acceptor or donor. Signaling may be obtained by directly detecting luminescence from the NC and/or the conjugate. New developments for the use of NCs as gain materials in micro-lasing cavities (distributed feedback gratings and spherical resonators) opens the way to designing CB-sensitive NCs for high-gain sensing applications.

Graphical abstract: CdSe nanocrystal based chem-/bio- sensors

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Publication details

The article was received on 11 Sep 2006 and first published on 27 Feb 2007

Article type: Tutorial Review
DOI: 10.1039/B517613C
Citation: Chem. Soc. Rev., 2007,36, 579-591
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    CdSe nanocrystal based chem-/bio- sensors

    R. C. Somers, M. G. Bawendi and D. G. Nocera, Chem. Soc. Rev., 2007, 36, 579
    DOI: 10.1039/B517613C

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