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Issue 2, 2007
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Chemical double-mutant cycles: dissecting non-covalent interactions

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Abstract

Thermodynamic double-mutant cycles and triple-mutant boxes are widely employed for the experimental quantification of non-covalent interactions and cooperative effects in proteins. This review describes the application of these powerful methodologies to the study of non-covalent interactions in synthetic systems.

Graphical abstract: Chemical double-mutant cycles: dissecting non-covalent interactions

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Publication details

The article was received on 24 Aug 2006 and first published on 27 Nov 2006


Article type: Tutorial Review
DOI: 10.1039/B603842P
Citation: Chem. Soc. Rev., 2007,36, 172-188
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    Chemical double-mutant cycles: dissecting non-covalent interactions

    S. L. Cockroft and C. A. Hunter, Chem. Soc. Rev., 2007, 36, 172
    DOI: 10.1039/B603842P

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