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Issue 2, 2007
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Functionalized cucurbiturils and their applications

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Cucurbit[n]uril (CB[n], n = 5–10), a new family of molecular hosts comprising n glycoluril units, have gained much attention in the new millennium for their exceptional molecular recognition ability. The CB homologues have brought dynamism to CB chemistry, as witnessed by the heightened interest in the field for the last several years. Compared to the chemistry of cyclodextrins and calixarenes, however, that of CB[n] has developed slowly until recently, which may be attributed mainly to their poor solubility in common solvents, and inability to functionalize these molecules. The direct functionalization method of CB[n] propelled CB chemistry to a new height as this new method not only solved the solubility problem but also opened up the gateway to the generation of tailor-made CB[n] derivatives. The functionalization of CB[n] led us to investigate numerous applications including artificial ion channels, vesicles, stationary phases in chromatography, ISEs, polymers, nanomaterials, and many others. This tutorial review describes the recent advances and challenges in the functionalization of CBs along with the applications of functionalized CBs.

Graphical abstract: Functionalized cucurbiturils and their applications

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Publication details

The article was received on 07 Sep 2006 and first published on 07 Nov 2006

Article type: Tutorial Review
DOI: 10.1039/B603088M
Citation: Chem. Soc. Rev., 2007,36, 267-279
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    Functionalized cucurbiturils and their applications

    K. Kim, N. Selvapalam, Y. H. Ko, K. M. Park, D. Kim and J. Kim, Chem. Soc. Rev., 2007, 36, 267
    DOI: 10.1039/B603088M

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