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Issue 1, 2007
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Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

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Abstract

The ring closing metathesis (RCM) is a powerful method in organic synthesis for the preparation of cyclic compounds by formation of new carbon–carbon bonds. In the past years a particular subclass of the RCM, the ring closing enyne metathesis (RCEYM), has attracted attention due to its synthetic potential in the generation of ring structures with 1,3-diene moieties, which can subsequently be further functionalised. In this tutorial review mechanistic considerations will be described and the synthetic power of this useful and attractive carbon–carbon bond forming reaction will be illustrated by recent examples of RCEYM applications in the preparation of heterocyclic compounds.

Graphical abstract: Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

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Publication details

The article was received on 02 Aug 2006 and first published on 04 Oct 2006


Article type: Tutorial Review
DOI: 10.1039/B508899M
Citation: Chem. Soc. Rev., 2007,36, 55-66
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    Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

    H. Villar, M. Frings and C. Bolm, Chem. Soc. Rev., 2007, 36, 55
    DOI: 10.1039/B508899M

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